| Oil and water phases | Droplets may merge after mixing, especially without suitable formulation. | Create a finer, more uniform emulsion and reduce visible droplet size. | Process the liquid mixture with any required surfactant or emulsifier. Use short trials and control temperature. | Droplet-size distribution, separation over time, temperature, and whether the formulation needs additional stabilization. |
| Pigments in a liquid carrier | Pigment agglomerates can cause uneven color, poor gloss, or settling. | Break down agglomerates and distribute pigment more evenly through the liquid. | Pre-wet the pigment where appropriate, then process the slurry using a probe suited to the batch volume and vessel. | Color uniformity, particle or agglomerate size, viscosity, temperature, and possible probe wear or contamination. |
| Nanoparticle suspensions | Fine particles can form persistent agglomerates and may reagglomerate after processing. | Reduce agglomeration and obtain a more uniform suspension. | Use controlled, incremental processing with effective cooling. Select the liquid medium and stabilizer for the particle system. | Particle-size distribution, stability over time, temperature, and any contamination from probe erosion. |
| Biological cells or soft tissue in suspension | Cells may need disruption, while excess heat or processing can damage temperature-sensitive components. | Lyse cells or release intracellular material while limiting unwanted heating. | Use pulsed operation and cooling as needed; process small test samples before scaling up. | Lysis efficiency, sample temperature, recovery of the desired material, and preservation of heat-sensitive compounds. |
| Viscous polymers, resins, or concentrated liquids | High viscosity can hinder circulation and reduce effective energy transfer through the sample. | Improve mixing or distribute an added component more uniformly. | Confirm that the disperser is suitable for the sample’s viscosity. Consider pre-mixing or dilution if compatible with the process. | Flow around the probe, uniformity throughout the vessel, temperature, and whether the sample remains processable. |
| Mineral or abrasive suspensions | Dense particles can settle; abrasive solids can wear a probe over time. | Break up soft agglomerates and distribute solids more evenly. | Keep solids suspended with appropriate vessel mixing and use brief trials to assess probe wear and sample compatibility. | Settling rate, particle distribution, probe condition, and potential metal contamination. |
| Fibers or delicate particles | Strong cavitation can shorten, fragment, or otherwise alter fragile structures. | Distribute material while retaining as much of its original structure as possible. | Begin with gentle, short processing trials and compare the sample before and after treatment. | Fiber length or particle shape, uniformity, and any loss of the properties the process is intended to preserve. |