| Product and ingredients | List every component, its physical form, particle-size distribution, moisture content, and any sensitivity to heat, shear, or contamination. | Example: three dry powder ingredients, with one minor ingredient requiring even distribution. | Ingredient properties affect mixing behavior, charging order, dust control, and the need for liquid addition or temperature monitoring. Confirm performance using representative materials. |
| Bulk density and batch mass | Measure loose bulk density and specify the required batch mass. Use the lowest expected bulk density when checking volume capacity. | Example: 500 kg per batch at a measured bulk density of 650 kg/m³. | Estimated material volume = batch mass ÷ bulk density. In this example, 500 ÷ 650 ≈ 0.77 m³ of material; vessel working volume must be larger and confirmed for the selected mixer. |
| Working volume and fill level | Specify minimum, normal, and maximum batch sizes. Ask for the mixer’s validated working-volume range; do not equate vessel capacity with usable batch volume. | Example: one 500 kg batch, with a future requirement for smaller development batches. | A mixer must mix effectively across the required operating range. Confirm minimum fill, maximum fill, and performance at both ends with the equipment supplier. |
| Throughput and schedule | Define required output per hour or shift and include charging, mixing, discharge, and routine changeover time in the cycle. | Example: a 40-minute total cycle allows 1.5 batches per hour, or 750 kg/hour at 500 kg per batch, before downtime. | Calculate practical output from batch mass and the complete cycle time—not mixing time alone. Allow for cleaning, inspection, and production interruptions. |
| Mixing quality | Set a measurable acceptance criterion, such as a specified coefficient of variation (CV) from representative samples or a product-specific assay limit. | Example: define the allowable CV and sampling locations in the product specification before testing. | The required uniformity depends on the product and test method. Validate mixing time and sampling procedure with production-representative ingredients and batch sizes. |
| Liquid addition, if required | Specify liquid type, dose per batch, addition time, viscosity, and whether spray distribution is needed. | Example: a controlled spray addition during mixing, with the required dose established by the formulation. | Discuss spray nozzles, feed location, liquid-flow control, and cleanability. Confirm that liquid addition will not cause unwanted agglomeration or wall buildup. |
| Discharge and downstream handling | Define the receiving equipment, discharge time, outlet arrangement, and acceptable residual material after emptying. | Example: discharge directly into a correctly sized hopper or conveying system within the planned cycle. | Outlet size and layout should suit the product’s flow properties and downstream equipment. Verify discharge performance with the actual material where possible. |
| Cleaning and product changeover | State cleaning method, changeover frequency, allowable carryover, access requirements, and whether wet cleaning is permitted. | Example: frequent product changes require documented inspection and cleaning access between batches. | Review access doors, seals, shaft areas, internal surfaces, and drainability where relevant. Confirm the cleaning procedure is compatible with the product and site standards. |
| Materials, environment, and safety | Identify corrosion risks, operating temperature, dust hazards, exposure controls, and applicable site or regulatory requirements. | Example: combustible dust or corrosive ingredients require a documented hazard and materials review. | Specify suitable construction materials, seals, guarding, dust extraction interfaces, and any required protection or certification with qualified safety and engineering personnel. |
| Utilities and installation | Check available electrical supply, installed power, compressed air if needed, floor loading, access, and connection points. | Example: confirm the planned installation area and utility capacity before finalizing the equipment layout. | Motor power and drive selection depend on the product, batch size, operating conditions, and mixer design; obtain a project-specific load and utility specification. |